How Adderexin Works


Adderexin works through a multitude of pathways but its main focus is to catalyze an increased availability of the neurotransmitter, Acetylcholine, in the brain.  Through Adderexin's synergistic effect of scientifically formulated ingredients, other neurotransmitters and cellular communications are increased as well.  


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Below is a more detailed description of Acetylcholine.


What Acetylcholine Is

ACh is a neurotransmitter.  Neurotransmitters are the chemical messengers that carry signals throughout the nerves in our bodies.  There is more ACh in our body than any other individual neurotransmitter.  It can be found in both the peripheral and central nervous systems.  
ACh interacts with particular cells located throughout the different regions of our brain. Specifically, the basal forebrain and the hippocampus.  These two regions are responsible for cognitive function and memory.  ACh promotes the growth of synapses between neurons and enhances the intensity and quality of the neuron signaling.



How Acetylcholine Is Created

Acetylcholine (ACh) is made of Choline and Acetyl Co-A.  Choline can be produced by the body in small amounts but comes mostly from our dietary intake.  Acetyl Co-A is produced by the mitochondria within our cells.  Choline acetyltransferase, known as ChAT, is the enzyme responsible for the synthesis of ACh. As Choline and Na+ enter into the nerve, ChAT combines the Acetyl Co-A together with the Choline and ACh is created within the cell.
The Vesicular acetylcholine transporter, known as VAChT is the enzyme which then moves ACh into a vesicle for storage and moves it to the end of the neuron.  Through a process known as exocytosis the ACh is released from the neuron into the synaptic cleft.

How Acetylcholine Works

In it’s capacity as an excitatory, ACh speeds up the communication of the signals in the central nervous system. The benefits to us include the following: assists in learning, memory, improved concentration and sensory perception.

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The "Mind-Muscle Connection"


There has been a cliche saying that has been in the sports and fitness industry for many decades.  This is known as the "mind-muscle" connection. Of course we know it is the brain which delivers the message to our muscles which tells our muscles to contract.  But the idea behind this connection goes much deeper than this simple statement.  It is the interaction between the nerve cell and the skeletal muscle to contract.  Moreover, 1 Nerve cell can stimulate hundreds of different skeletal muscle cells.

This all is triggered through Acetylcholine.

First the brain send the message through the neuron.  This message is known as the action potential.  It comes from the brain to the neuron through to the axon terminal.  This causes calcium channels to open up and the calcium ions enter the cell.  These calcium ions then cause SNARE proteins to attach themselves to the acetylcholine in the neuron.  This then causes the acetylcholine to fuse with the presynaptic membrane.  This is the outermost wall of the neuron.  At this point a process happens which is known as exocystosis or the "leaving" of the acetylcholine from end of the neuron and into the synaptic cleft

Once in the synaptic cleft, the acetylcholine finds it's specific receptors.  It then attaches to the acetylcholine receptors which are sodium channels. Once the acetylcholine has attached, the channels open and sodium ions enter into the muscle cell.  Since the sodium ion is positively charged it causes the muscle cell to become extremely positively charged. Once the threshold level is reached (+30mV) it stimulates an action potential in the muscle cell which causes other volted gated channels to open and sodium rushes into the cell.  The rush of sodium ions causes voltage gated calcium release.  Thus, a flood of calcium ions are released.  These calcium ions are in such abundance that it causes the sarcoplasmic reticulum to release it's stored calcium. This is known as calcium induced calcium release.  Muscle cells are attached to each other through gap junctions and allow the surplus of calcium ions to go from one muscle cell to the next.  In other words, as one muscle cell contracts and has an abundance of calcium it transfers it's "over flow" into the next muscle cell causing the next cell to contract and to the next muscle cell to contract and so on.  This flow is known as syncytium, and the muscle cells are contracting in synergy.  The more muscle cells that are recruited and capable of contracting the stronger we are.